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Product patents expired, including mevacor, prinivil, prinzide lisinopril and hydrochlorothiazide and vaseretic.
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Renovascular HypertensionSome patients with renovascular hypertensionespecially those with bilateral renal artery stenosis or stenosis of the artery to a solitary kidneymay develop an exaggerated response to the first dose of lisinoprilThereforea lower starting dose of 2.5 or 5 mg is recommendedThereafterthe dosage may be adjusted according to the blood pressure response.
Anaphylactoid Reactions during Hymenoptera DesensitizationThere have been isolated reports of patients experiencing sustained life-threatening anaphylactoid reactions while receiving ACE inhibitors during desensitizing treatment with hymenopterabeeswaspsvenomIn the same patientsthese reactions have been avoided when ACE inhibitors were temporarily withheld for at least 24 hoursbut they have reappeared upon inadvertent rechallenge.
Dosage And AdministrationSince absorption of lisinopril is not affected by foodthe tablets may be administered beforeduring or after mealsLisinopril should be administered in a single daily dose.
HyperkalemiaPatients should be told not to use salt substitutes containing potassium without consulting their physician.
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